clinical trials and the extent to which safety and effectiveness data is based on demographic factors such as sex, age, and race. The Center has responded with the Drug Trials Snapshots program to

Promising results from preclinical trials in human xenograft mice and a few clinical pilote studies reveal that salinomycin is able to effectively eliminate CSCs and to induce partial clinical

Salinomycin was administered to chickens intravenously, in the left wing vein, at a dose of 0.25 mg /kg and orally at a dose of 2.5 mg /kg. Residue studies were carried out with supplemented feed at the rate of 100 mg /kg of feed for monensin in turkeys and 70 mg /kg for salinomycin in chickens, respectively. Promising results from preclinical trials in human xenograft mice and a few clinical pilote studies reveal that salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. Based on these findings, salinomycin was therapeutically applicated "first-in-man" in 2010, in the context of a pilot clinical trial with a small cohort of patients with metastatic breast, ovarian, and head and neck cancers. Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, or other pathways.

Salinomycin clinical trial

Chester, New Jersey, February 10, 2020 – Hillstream BioPharma Inc. (“Hillstream”), a near-clinical stage biotechnology company focused on rare, orphan and unmet need cancers announced today, acquisition of a salinomycin analogue portfolio with related global patents, non-clinical data, other filings Based on these findings, salinomycin was therapeutically applicated "first-in-man" in 2010, in the context of a pilot clinical trial with a small cohort of patients with metastatic breast, ovarian, and head and neck cancers. http://www.hindawi.com/ Although Sal exhibits predominant anticancer effects in vivo and in vitro experiments and a small number of clinical trials, the exact mechanisms are still unknown. We summarize the autophagy-related researches, providing a new sight into Sal’s preference for CSCs and cancer cells. 2019-02-14 Promising results from preclinical trials in human xenograft mice and a few clinical pilote studies reveal that salinomycin is able to effectively eliminate CSCs and to induce partial clinical The major obstacle for clinical application of salinomycin is its systemic toxicity in vivo, with a narrow margin of safety (Dewangan et al., 2017). Our results revealed great potential of salinomycin for treatment of colorectal cancer. Monensin, lasalocid, salinomycin, narasin and maduramicin are carboxylic ionophores commonly used as anticoccidial drugs for poultry and as growth promotants for ruminants.Horses are the most susceptible species for ionophore toxicity and other domestic animals are also susceptible.

2019-11-13 Promising results from preclinical trials in human xenograft mice and a few clinical pilote studies reveal that salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers.

2020-11-30

Clinical trial: N/A. Reference: [1] Wang F,He L,Dai WQ,Xu YP,Wu D,Lin CL,Wu SM,Cheng P,Zhang Y,Shen M,Wang CF,Lu J,Zhou YQ,Xu XF,Xu L,Guo CY. Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo. PLoS One.2012;7(12):e50638. RESEARCH ARTICLE Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model Johannes Klose ID 1*, Stefan Trefz1, Tobias Wagner1, Luca Steffen1, Arsalie Preißendo¨ rfer Charrier1, Praveen Radhakrishnan1, Claudia Volz1, Thomas Schmidt ID 1, Alexis Ulrich1, Sebastian M. Dieter2, Claudia Ball3, Hanno Glimm2,3,4,5, Martin Schneider1 1 Department of General, Visceral and The ionophore salinomycin has been shown to kill cancer stem cells and is therefore a promising future salinomycin's mechanism of action is of great importance to understanding salinomycin's safety and potential for clinical application.

Salinomycin, an antibacterial therapeutic drug, has emerged as an effective drug toward various CSCs in a variety of cancers 9. It was first discovered by Gupta et al who used a high-throughput

Salinomycin a broad spectrum ionophore anticoccidial, was evaluated for toleration and efficacy at 60 ppm in the feed of broiler reared to market weig… Promising results from preclinical trials in human xenograft mice and a few clinical pilote studies reveal that salinomycin is able to effectively eliminate CSCs and to induce partial clinical Although Sal exhibits predominant anticancer effects in vivo and in vitro experiments and a small number of clinical trials, the exact mechanisms are still unknown. We summarize the autophagy-related researches, providing a new sight into Sal’s preference for CSCs and cancer cells. The release kinetic of salinomycin from the nanofibers was assessed at 37 °C in PBS buffers at different pH levels to mimic the tumor environment (pH 6) and normal extracellular fluid or blood (pH Salinomycin News and Research RSS. Study identifies a host of agents with anti-SARS-CoV-2 potential. A team of researchers at the Genomics Research Center, Academia Sinica, in Taiwan, evaluated Salinomycin is a powerful cancer treatment.

http://www.hindawi.com/ Although Sal exhibits predominant anticancer effects in vivo and in vitro experiments and a small number of clinical trials, the exact mechanisms are still unknown. We summarize the autophagy-related researches, providing a new sight into Sal’s preference for CSCs and cancer cells. 2019-02-14 Promising results from preclinical trials in human xenograft mice and a few clinical pilote studies reveal that salinomycin is able to effectively eliminate CSCs and to induce partial clinical The major obstacle for clinical application of salinomycin is its systemic toxicity in vivo, with a narrow margin of safety (Dewangan et al., 2017). Our results revealed great potential of salinomycin for treatment of colorectal cancer. Monensin, lasalocid, salinomycin, narasin and maduramicin are carboxylic ionophores commonly used as anticoccidial drugs for poultry and as growth promotants for ruminants.Horses are the most susceptible species for ionophore toxicity and other domestic animals are also susceptible.
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Residue studies were carried out with supplemented feed at the rate of 100 mg /kg of feed for monensin in turkeys and 70 mg /kg for salinomycin in chickens, respectively.

av X Huang · 2018 · Citerat av 30 — The natural product salinomycin, a K+-selective ionophore, was recently Cecilia Hegardt - Department of Clinical Sciences Lund, Division of Find, read and cite all the research you need on ResearchGate. Palatability of Diets for Channel Catfish that Contain Amprolium or Salinomycin Using Feed that fish readily consumed the basal control diet containing no drug and diets Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs. Xiaoli Huang, Björn Borgström, Sebastian Kempengren, Lo Persson, cancer treatment: Study protocol for the ReScreen randomized controlled trial Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin By screening 1,600 compounds with documented clinical history, we aimed to identify nitazoxanide, niclosamide, closantel, pyrvinium pamoate, and salinomycin. could be a potential candidate for advancement into cancer clinical trials.
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Although Sal exhibits predominant anticancer effects in vivo and in vitro experiments and a small number of clinical trials, the exact mechanisms are still unknown. We summarize the autophagy-related researches, providing a new sight into Sal’s preference for CSCs and cancer cells.

Antiproliferative effects of salinomycin and TRAIL on GBM cell lines We have evaluated the effect of salinomycin on the proliferation of three human glioblastoma cell lines, U87MG, U251 and T98G. salinomycin in the feed additive, premixtures and feedingstuffs. For the quantification of salinomycin in chicken tissues the Applicant submitted a single laboratory validated and further verified method based on reverse phase HPLC coupled to a triple quadrupole mass spectrometer in electrospray ionisation mode using matrix Sacox® microGranulates, containing salinomycin sodium (SAL-Na), for chickens for fattening and chickens reared for laying have been recently re-evaluated by Panel on Additives and Products or Substances used in Animal Feed. Following an urgent request from the European Commission, the safety and efficacy of the product when fed to rabbits for fattening was assessed based on the available data Salinomycin sodium (SAL-Na) is active against certain Gram-positive bacteria, while Gram-negative species are resistant.

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28 Aug 2015 A phase of research to describe clinical trials that focus on the safety of a drug. They are usually conducted with healthy volunteers, and the goal

In trial 1, addition of salinomycin at 5.5, 11 or 22 ppm to 60% concentrate diets fed to ruminal-cannulated rams had no effect (P greater than .05) on apparent digestibility of dry matter (DM Low-dose salinomycin induces anti-leukemic responses in AML and MLL. Gary D R Roulston, Charlotte L Burt, Laura M J Kettyle, Kyle B Matchett, Heather L Keenan, Nuala M Mulgrew, Joanne M Ramsey, Caoifa Dougan, John McKiernan, Ivan V Grishagin, Ken I Mills, Alexander Thompson. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Clinical trial: N/A. Reference: [1] Wang F,He L,Dai WQ,Xu YP,Wu D,Lin CL,Wu SM,Cheng P,Zhang Y,Shen M,Wang CF,Lu J,Zhou YQ,Xu XF,Xu L,Guo CY. Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo.